CME INFORMATION

FACULTY AFFILIATIONS AND DISCLOSURES

Case Studies

Case 1: A 74-year-old man who presented five years ago with a Grade III, ER-positive, PR-positive, HER2-negative infiltrating ductal carcinoma with 2/8 positive lymph nodes, for which he underwent a modified left radical mastectomy and local chest wall radiation therapy followed by AC paclitaxel and tamoxifen. After 4.5 years, he presented with back pain and elevated CA27.29. PET revealed multiple abnormal bony sites in the ribs and spine, two small hepatic lesions and supraclavicular nodes (from the practice of Dr David M Dresdner)

Case 2: A 39-year-old woman with a 1.7-centimeter, Grade II, ER-positive, PR-positive, HER2-negative infiltrating ductal carcinoma with 7/10 positive lymph nodes (from the practice of Dr Atif M Hussein)

Case 3: A 49-year-old woman who presented with a palpable right breast mass and underwent a lumpectomy that revealed a 1.5-centimeter, Grade I, ER-positive, PR-positive, HER2-positive infiltrating ductal carcinoma with intermediate-grade DCIS and negative sentinel lymph node biopsy (from the practice of Dr Carolyn B Hendricks)

Case 4: A 56-year-old woman who underwent a left lumpectomy for a 3.1-centimeter, moderately differentiated, ER-negative, PR-negative, HER2-negative infiltrating ductal carcinoma with 3/12 positive axillary lymph nodes. She received TAC and radiation therapy. In less than one year, CEA and CA15-3 increased and CT scan revealed several hepatic lesions, largest measuring 1.6 centimeters (from the practice of Dr Atif M Hussein)

Case 5: A 60-year-old woman who was treated three years ago for a Stage I, ER-positive, HER2-positive left breast cancer with mastectomy and adjuvant AC and tamoxifen. Recently, she presented with a Stage IIIA, ER-positive, PR-positive, HER2-positive contralateral breast cancer with six positive nodes (from the practice of Dr Carolyn B Hendricks)

Case 6: An active 82-year-old woman with a 1.7-centimeter, weakly ER-positive, PR-positive, HER2-negative, poorly differentiated breast tumor with two positive nodes (from the practice of Dr Alan B Astrow)

Case 7: A 38-year-old woman of Ashkenazi descent with no family history of breast or ovarian cancer, who presented with a T1N1 ER-positive, PR-positive, HER2-negative invasive lobular carcinoma <2 centimeters with 1/12 positive lymph nodes. The patient underwent a mastectomy but refused adjuvant therapy. Seven years later she presented with a second primary breast cancer and metastatic disease (from the practice of Dr Richard S Zelkowitz)

Case 8: A 32-year-old woman who presented with a six-centimeter, Grade II, ER-positive, PR-negative, HER2-positive infiltrating ductal carcinoma at 34 weeks of pregnancy (from the practice of Dr Michael A Schwartz)

Case 9: A healthy and independent 97-year-old woman with osteopenia who underwent a mastectomy for a five-centimeter, ER-positive, PR-positive, HER2-negative infiltrating ductal carcinoma (from the practice of Dr Richard S Zelkowitz)

Case 10: A 34-year-old woman who presented with a four-centimeter, high-grade, ER-positive, PR-positive, HER2-positive breast cancer with extensive lymphovascular invasion and 3/20 positive nodes (from the practice of Dr Patricia A De Fusco)

Case 11: A 39-year-old woman who presented with a 0.9-centimeter, Grade II, ER-positive, PR-negative, HER2-negative lobular carcinoma with 1/9 positive nodes (from the practice of Dr David M Dresdner)